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Biosynthesis of cofactors

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
pyridoxine_5''-phosphate + H2O <=> pyridoxine + phosphate 3.1.3.2 acid phosphatase
3.1.3.74 pyridoxal phosphatase
–
–
S-adenosyl-L-methionine + precorrin-5 + H2O <=> H+ + precorrin-6A + S-adenosyl-L-homocysteine + acetate 2.1.1.152 precorrin-6A synthase (deacetylating)
–
5,6,7,8-tetrahydromethanopterin + acceptor <=> 7,8-dihydromethanopterin + reduced_acceptor 1.5.99.15 dihydromethanopterin reductase (acceptor)
–
S-adenosyl-L-methionine + precorrin-3B <=> H+ + precorrin-4 + S-adenosyl-L-homocysteine 2.1.1.131 precorrin-3B C17-methyltransferase
–
pimelyl-[acyl-carrier_protein]_methyl_ester + H2O <=> pimeloyl-[acyl-carrier_protein] + methanol + H+ 3.1.1.85 pimelyl-[acyl-carrier protein] methyl ester esterase
–
NH3 + ATP + deamido-NAD+ <=> H+ + AMP + diphosphate + NAD+ 6.3.1.5 NAD+ synthase
6.3.5.1 NAD+ synthase (glutamine-hydrolysing)
–
–
peptidyl-4-carboxyglutamate + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + H+ + H2O <=> CO2 + peptidyl-glutamate + vitamin_KH2 + O2 4.1.1.90 peptidyl-glutamate 4-carboxylase
–
ATP + tetrahydrofolate + L-glutamate <=> ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2 6.3.2.17 tetrahydrofolate synthase
–
[Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine + an_[Fe-S]_cluster_scaffold_protein_carrying_a_[4Fe-4S]2+_cluster + 2 S-adenosyl-L-methionine + 2 [2Fe-2S]-center + 8 H+ <=> enzyme_N6-(dihydrolipoyl)lysine + an_[Fe-S]_cluster_scaffold_protein + 2 Sulfide + 4 Fe2+ + 2 L-methionine + 2 5''-Deoxyadenosine + 2 [2Fe-2S]-center 2.8.1.8 lipoyl synthase
–
pantothenate + ATP <=> H+ + (R)-4''-phosphopantothenate + ADP 2.7.1.169 pantoate kinase
2.7.1.33 pantothenate kinase
–
–
NAD+ + ATP <=> H+ + NADP+ + ADP 2.7.1.23 NAD+ kinase
–
UDP-glucuronate + rhodopsin <=> UDP + a_beta-D-glucuronoside 2.4.1.17 glucuronosyltransferase
–
nicotinic_acid_mononucleotide + 5,6-Dimethylbenzimidazole <=> alpha-ribazole_5''-phosphate + nicotinate + H+ 2.4.2.21 nicotinate-nucleotide---dimethylbenzimidazole phosphoribosyltransferase
2.4.2.55 nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
–
–
chorismate <=> 3-[(1-carboxyvinyl)oxy]benzoate + H2O 4.2.1.151 chorismate dehydratase
–
adenylyl-molybdopterin + molybdate + H+ <=> molybdenum_cofactor + AMP + H2O 2.10.1.1 molybdopterin molybdotransferase
–
adenosylcobyrinic_acid_a,c-diamide + L-glutamine + ATP + H2O <=> H+ + L-glutamate + adenosylcobyric_acid + ADP + phosphate 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)
–
cyclic_dehypoxanthinyl_futalosine <=> 1,4-dihydroxy-6-naphthoate 1.14
–
CoA + heptanedioate + ATP <=> pimeloyl-CoA + diphosphate + AMP 6.2.1.14 6-carboxyhexanoate---CoA ligase
6.2.1.23 dicarboxylate---CoA ligase
–
–
L-dihydroorotate + fumarate <=> Orotate + succinate 1.3.98.1 dihydroorotate dehydrogenase (fumarate)
–
(S)-4-Amino-5-oxopentanoate <=> 5-aminolevulinate 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase
–
ATP + Ni-sirohydrochlorin_a,c-diamide + reduced_acceptor + H2O <=> ADP + phosphate + 15,173-seco-F430-173-acid + acceptor 6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase
–
(R)-4''-phosphopantothenate + L-cysteine + CTP <=> H+ + (R)-4''-phosphopantothenoyl-L-cysteine + diphosphate + CMP 6.3.2.5 phosphopantothenate---cysteine ligase (CTP)
–
H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + riboflavin 2.5.1.9 riboflavin synthase
–
ATP + adenosylcobyric_acid + (R)-1-aminopropan-2-ol <=> H+ + ADP + phosphate + adenosylcobinamide 6.3.1.10 adenosylcobinamide-phosphate synthase
–
Enoylpimeloyl-[acp]_methyl_ester + NADPH + H+ <=> pimelyl-[acyl-carrier_protein]_methyl_ester + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
–
L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase
–
–
–
–
a_demethylmenaquinol + S-adenosyl-L-methionine <=> menaquinol + S-adenosyl-L-homocysteine 2.1.1.163 demethylmenaquinone methyltransferase
–
L-glutamate + L-cysteine + ATP <=> gamma-Glu-L-Cys + ADP + phosphate + H+ 6.3.2.2 glutamate---cysteine ligase
–
S-adenosyl-L-methionine + (8S)-8-amino-7-oxononanoate <=> S-adenosyl-4-methylthio-2-oxobutanoate + (7R,8S)-diaminononanoate 2.3.1.47 8-amino-7-oxononanoate synthase
2.6.1.62 adenosylmethionine---8-amino-7-oxononanoate transaminase
–
–
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ 3.5.4.9 methenyltetrahydrofolate cyclohydrolase
–
tetrahydrobiopterin + NADP+ <=> biopterin + NADPH + H+ 1.5.1.33 pteridine reductase
–
H+ + adenosylcobinamide_phosphate + GTP <=> adenosylcobinamide-GDP + diphosphate 2.7.1.156 adenosylcobinamide kinase
2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase
–
–
2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate + ATP <=> 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + ADP 2.7.1.49 hydroxymethylpyrimidine kinase
2.7.4.7 phosphooxymethylpyrimidine kinase
–
–
tetrahydrobiopterin + NADP+ <=> (6R)-L-erythro-6,7-dihydrobiopterin + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
–
–
–
S-adenosyl-L-methionine + precorrin-2 <=> H+ + S-adenosyl-L-homocysteine + precorrin-3A 2.1.1.130 precorrin-2 C20-methyltransferase
–
dihydrolipoylprotein + Lipoyl-carrier_protein_E2 <=> glycine_cleavage_system_H + enzyme_N6-(dihydrolipoyl)lysine not assigned
 –
nonaprenyl_diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate 2.5.1.117 homogentisate solanesyltransferase
–
S-adenosyl-L-methionine + 5-amino-1-(5-phospho-D-ribosyl)imidazole <=> 2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate + 5''-deoxyadenosine + L-methionine + formate + CO + H+ 4.1.99.17 phosphomethylpyrimidine synthase
–
pyridoxal + ATP <=> pyridoxal_5''-phosphate + H+ + ADP 2.7.1.35 pyridoxal kinase
–
3-Hydroxyanthranilate + O2 <=> alpha-amino-beta-carboxymuconate-epsilon-semialdehyde 1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase
–
(R)-pantoate + NADP+ <=> H+ + ketopantoate + NADPH 1.1.1.169 2-dehydropantoate 2-reductase
1.1.1.86 ketol-acid reductoisomerase (NADP+)
–
–
1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> H+ + 1,4-dihydroxy-2-naphthoate + CoA 3.1.2.28 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
–
3-Ketoglutaryl-[acp]_methyl_ester + NADPH + H+ <=> 3-Hydroxyglutaryl-[acp]_methyl_ester + NADP+ 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
–
Hydroxymethylbilane <=> uroporphyrinogen_III + H2O 4.2.1.75 uroporphyrinogen-III synthase
–
ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate 2.5.1.6 methionine adenosyltransferase
–
H+ + L-tyrosine <=> CO2 + tyramine 4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
–
–
beta-Alanine + (R)-pantoate + ATP <=> H+ + pantothenate + diphosphate + AMP 6.3.2.1 pantoate---beta-alanine ligase (AMP-forming)
–
thiamine + ATP <=> H+ + thiamine_diphosphate + AMP 2.7.6.2 thiamine diphosphokinase
–
chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate 2.6.1.85 aminodeoxychorismate synthase
–
H+ + glycine + succinyl-CoA <=> CO2 + CoA + 5-aminolevulinate 2.3.1.37 5-aminolevulinate synthase
–
(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <=> (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate 4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
–
tRNAMet + L-glutamate + ATP <=> Glu-tRNAGln + diphosphate + AMP 6.1.1.17 glutamate---tRNA ligase
6.1.1.24 glutamate---tRNAGln ligase
–
–
dihomocitrate <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase
–
S-adenosyl-L-methionine + malonyl-[acyl-carrier_protein] <=> malonyl-[acyl-carrier_protein]_methyl_ester + S-adenosyl-L-homocysteine 2.1.1.197 malonyl-[acyl-carrier protein] O-methyltransferase
–
L-aspartate + NADP+ <=> iminosuccinate + NADPH + H+ 1.4.1.21 aspartate dehydrogenase
–
Hydrogenobyrinate + L-glutamine + ATP + H2O <=> H+ + L-glutamate + hydrogenobyrinic_acid_a,c-diamide + ADP + phosphate 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
UDP + ATP <=> UTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
S-adenosyl-L-methionine + 2-methoxy-6-polyprenyl-1,4-benzoquinol <=> 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
–
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + H2O <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + phosphate 3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
–
ADP + ATP <=> ATP + ADP 2.4.2.12 nicotinamide phosphoribosyltransferase
2.7.1.20 adenosine kinase
2.7.4.6 nucleoside-diphosphate kinase
3.6.4.10 non-chaperonin molecular chaperone ATPase
–
–
–
–
protoporphyrinogen-IX + 3 acceptor <=> protoporphyrin_IX + 3 reduced_acceptor 1.3.99
–
beta-L-galactose_1-phosphate + H2O <=> L-galactopyranose + phosphate 3.1.3.93 L-galactose 1-phosphate phosphatase
3.1.3.B9
–
–
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoic_acid <=> 7,8-dihydropteroate + H2O 2.5.1
2.5.1.15 dihydropteroate synthase
–
–
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one_4-phosphate <=> H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine + phosphate + H2O 2.5.1.78 6,7-dimethyl-8-ribityllumazine synthase
2.5.1.9 riboflavin synthase
–
–
3-geranyl-4-hydroxybenzoate + H+ <=> 2-polyprenylphenol + CO2 4.1.1.98 4-hydroxy-3-polyprenylbenzoate decarboxylase
–
tetrahydrobiopterin + NADP+ <=> 6-pyruvoyltetrahydropterin + NADPH + H+ 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
–
5,6,7,8-tetrahydromethanopterin + NADP+ <=> 7,8-dihydromethanopterin + NADPH + H+ 1.5.1.47 dihydromethanopterin reductase [NAD(P)+]
–
tetrahydrofolate + H2O <=> tetrahydrofolate + L-glutamate 3.4.19.9 folate gamma-glutamyl hydrolase
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iminosuccinate + dihydroxyacetone_phosphate <=> quinolinic_acid + H2O + phosphate 2.5.1.72 quinolinate synthase
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alpha-D-glucose_1-phosphate + UTP + H+ <=> UDP-glucose + diphosphate 2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
–
–
–
–
–
–
2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + NADP+ <=> 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + NADPH + H+ 1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
–
5-(aminomethyl)-3-furanmethanol_phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl_diphosphate + ADP 2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
–
octanoyl-[acyl-carrier_protein] + Lipoyl-carrier_protein_E2 <=> [Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine + [acyl-carrier_protein] 2.3.1.181 lipoyl(octanoyl) transferase
–
sirohydrochlorin + Fe2+ <=> H+ + siroheme 4.99.1.3 sirohydrochlorin cobaltochelatase
4.99.1.4 sirohydrochlorin ferrochelatase
–
–
S-adenosyl-L-methionine + uroporphyrinogen_III <=> S-adenosyl-L-homocysteine + precorrin-2 + H+ 2.1.1.107 uroporphyrinogen-III C-methyltransferase
–
L-3-hydroxykynurenine + H2O <=> H+ + 3-Hydroxyanthranilate + L-alanine 3.7.1.3 kynureninase
–
2 ATP + 2 cob(II)yrinic_acid_a,c-diamide + reduced_flavodoxin <=> 2 tripolyphosphate + 2 adenosylcobyrinic_acid_a,c-diamide + flavin 2.5.1.17 corrinoid adenosyltransferase
–
(-)-threo-iso(homo)3citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH 1.1.1
–
nicotinamide + H2O <=> NH3 + nicotinate 3.5.1.13 aryl-acylamidase
3.5.1.19 nicotinamidase
3.5.1.4 amidase
–
–
–
NTP + AMP <=> NDP + ADP 2.7.4.10 nucleoside-triphosphate---adenylate kinase
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H+ + H2O + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH3 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase
–
S-adenosyl-L-methionine + cobalt-factor_III + reduced_acceptor <=> S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor 2.1.1.272 cobalt-factor III methyltransferase
–
5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase
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N-formyl-L-kynurenine + H2O <=> L-kynurenine + formate + H+ 3.5.1.9 arylformamidase
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ATP + Octanoate + Lipoyl-carrier_protein_E2 <=> [Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine + AMP + diphosphate 6.3.1.20 lipoate---protein ligase
–
D-mannose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
octanoyl-[acyl-carrier_protein] + glycine_cleavage_system_H <=> [glycine_cleavage_system_H]-N6-octanoyl-L-lysine + [acyl-carrier_protein] 2.3.1.181 lipoyl(octanoyl) transferase
–
1,4-dihydroxy-6-naphthoate <=> menaquinone not assigned
 –
4-phospho-D-erythronate + NAD+ <=> H+ + 3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + NADH 1.1.1.290 4-phosphoerythronate dehydrogenase
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ATP + 15,173-seco-F430-173-acid <=> ADP + phosphate + coenzyme_F430 6.4.1.9 coenzyme F430 synthetase
–
heme_O <=> heme_a not assigned
 –
(2S)-lactyl-2-diphospho-5''-guanosine + coenzyme_F0 <=> GMP + coenzyme_F420-0 2.7.8.28 2-phospho-L-lactate transferase
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precorrin-3A + O2 + NADH + H+ <=> precorrin-3B + H2O + NAD+ 1.14.13.83 precorrin-3B synthase
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7,8-dihydroneopterin_3''-triphosphate <=> 6-pyruvoyltetrahydropterin + tripolyphosphate + H+ 4.2.3.12 6-pyruvoyltetrahydropterin synthase
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alpha-amino-beta-carboxymuconate-epsilon-semialdehyde <=> quinolinic_acid + H2O + H+ not assigned
 –
orotidine_5''-phosphate + diphosphate <=> 5-phospho-alpha-D-ribose_1-diphosphate + Orotate 2.4.2.10 orotate phosphoribosyltransferase
–
ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> H+ + ADP + 2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate 2.7.1.35 pyridoxal kinase
2.7.1.49 hydroxymethylpyrimidine kinase
2.7.4.7 phosphooxymethylpyrimidine kinase
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–
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UDP-glucuronate <=> UDP-D-galacturonate 5.1.3.6 UDP-glucuronate 4-epimerase
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7,8-dihydroneopterin <=> glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 4.1.2.25 dihydroneopterin aldolase
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L-aspartate + Carbamoyl_phosphate <=> H+ + L-carbamoyl-L-aspartate + phosphate 2.1.3.2 aspartate carbamoyltransferase
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(2S)-2-phospholactate + GTP + H+ <=> L-lactyl-2-diphospho-5''-guanosine + diphosphate 2.7.7.68 2-phospho-L-lactate guanylyltransferase
–
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate <=> o-succinylbenzoate + H2O 4.2.1.113 o-succinylbenzoate synthase
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(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate 3.1.3.71 2-phosphosulfolactate phosphatase
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FADH2 + NADP+ <=> FAD + NADPH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.2 ferredoxin---NADP+ reductase
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.45 FAD reductase [NAD(P)H]
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–
–
–
–
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futalosine + H2O <=> dehypoxanthine_futalosine + hypoxanthine 3.2.2.26 futalosine hydrolase
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4-(hydroxymethyl)-2-furancarboxaldehyde_phosphate + L-alanine <=> 5-(aminomethyl)-3-furanmethanol_phosphate + pyruvate 2.6.1.108 (5-formylfuran-3-yl)methyl phosphate transaminase
–
a_beta-D-glucuronoside + H2O <=> D-glucuronate + an_alcohol 3.2.1.31 beta-glucuronidase
–
alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase
–
–
–
hydrogenobyrinic_acid_a,c-diamide + Co2+ + ATP + H2O <=> H+ + cob(II)yrinic_acid_a,c-diamide + ADP + phosphate 6.6.1.2 cobaltochelatase
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demethylphylloquinone + NADPH + H+ <=> demethylphylloquinol + NADP+ 1.6.5.12 demethylphylloquinone reductase
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4-(phosphonooxy)-L-threonine + NAD+ <=> 2-amino-3-oxo-4-phosphonooxybutyrate + NADH 1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase
–
sirohydrochlorin + Co2+ <=> cobalt-sirohydrochlorin + H+ 4.99.1.3 sirohydrochlorin cobaltochelatase
4.99.1.4 sirohydrochlorin ferrochelatase
–
–
cobalt-precorrin-8 <=> cobyrinate + H+ 5.4.99.60 cobalt-precorrin-8 methylmutase
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dihomocitrate + CoA + H+ <=> 2-oxoadipate + acetyl-CoA + H2O 2.3.3
4.1.3
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L-dihydroorotate + a_quinone <=> Orotate + a_quinol 1.3.5.2 dihydroorotate dehydrogenase (quinone)
–
1-deoxy-D-xylulose_5-phosphate + 3-amino-1-hydroxyacetone_1-phosphate <=> H+ + pyridoxine_5''-phosphate + phosphate + H2O 2.6.99.2 pyridoxine 5'-phosphate synthase
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5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+ <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+ 1.1.1.193 5-amino-6-(5-phosphoribosylamino)uracil reductase
–
S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol <=> plastoquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.295 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
–
CoA + octanoyl-[acyl-carrier_protein] <=> [acyl-carrier_protein] + octanoyl-CoA 2.3.1
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.85 fatty-acid synthase system
2.8.3
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–
–
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S-adenosyl-L-methionine + Fe-coproporphyrin_III <=> heme + CO2 + 5''-deoxyadenosine + L-methionine 1.3.98.6 AdoMet-dependent heme synthase
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ADP-5-ethyl-4-methylthiazole-2-carboxylate + H2O <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl_phosphate + AMP not assigned
 –
(R)-4-phosphopantoate + beta-Alanine + ATP <=> (R)-4''-phosphopantothenate + AMP + diphosphate + H+ 6.3.2.36 4-phosphopantoate---beta-alanine ligase
–
geranyl_diphosphate + 1,4-dihydroxy-2-naphthoate <=> a_demethylmenaquinol + diphosphate + CO2 2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase
–
(8S)-3,8-cyclo-7,8-dihydroguanosine_5''-triphosphate <=> cyclic_pyranopterin_phosphate + diphosphate 4.6.1.17 cyclic pyranopterin monophosphate synthase
–
Ni-sirohydrochlorin + L-glutamine + ATP + H2O <=> Ni-sirohydrochlorin_a,c-diamide + L-glutamate + ADP + phosphate + H+ 6.3.5.12 Ni-sirohydrochlorin a,c-diamide synthase
–
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + dithiothreitol <=> vitamin_K + oxidized_dithiothreitol 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)
1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)
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–
glycine + gamma-Glu-L-Cys + ATP <=> glutathione + ADP + phosphate + H+ 6.3.2.3 glutathione synthase
–
all-trans-retinol + NADP+ <=> all-trans-retinal + NADPH + H+ 1.1.1
1.1.1.105 all-trans-retinol dehydrogenase (NAD+)
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.188 prostaglandin-F synthase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.300 NADP-retinol dehydrogenase
1.1.1.315 11-cis-retinol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
–
–
–
–
–
–
–
–
–
3-Hydroxypimeloyl-[acp]_methyl_ester <=> Enoylpimeloyl-[acp]_methyl_ester + H2O 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
–
3-Hydroxyglutaryl-[acp]_methyl_ester <=> Enoylglutaryl-[acp]_methyl_ester + H2O 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
–
L-gulono-1,4-lactone + O2 <=> ascorbate + H2O2 + H+ 1.1.3.8 L-gulonolactone oxidase
–
H+ + 4''-phosphopantetheine + ATP <=> 3''-dephospho-CoA + diphosphate 2.7.7.3 pantetheine-phosphate adenylyltransferase
–
folate + NADPH <=> tetrahydrofolate + NADP+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
–
–
–
Fe-coproporphyrin_III + H2O2 + H+ <=> heme + CO2 + H2O 1.3.98.5 hydrogen peroxide-dependent heme synthase
–
S-adenosyl-L-methionine + GTP + reduced_acceptor <=> (8S)-3,8-cyclo-7,8-dihydroguanosine_5''-triphosphate + L-methionine + 5''-deoxyadenosine + acceptor + H+ 4.1.99.22 GTP 3',8-cyclase
–
H+ + 3-sulfopyruvate <=> 2-sulfoacetaldehyde + CO2 4.1.1.79 sulfopyruvate decarboxylase
4.1.1.82 phosphonopyruvate decarboxylase
–
–
S-adenosyl-L-methionine + dehypoxanthine_futalosine <=> cyclic_dehypoxanthinyl_futalosine + L-methionine + 5''-deoxyadenosine + H+ 1.21.98.1 cyclic dehypoxanthinyl futalosine synthase
–
H+ + precorrin-8X <=> Hydrogenobyrinate 5.4.99.61 precorrin-8X methylmutase
–
ATP + AMP <=> ADP 1.13.12.7 firefly luciferase
2.7.1.20 adenosine kinase
2.7.4.10 nucleoside-triphosphate---adenylate kinase
2.7.4.11 (deoxy)adenylate kinase
2.7.4.14 UMP/CMP kinase
2.7.4.3 adenylate kinase
2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
2.7.4.9 dTMP kinase
–
–
–
–
–
–
–
–
–
–
O2 + pyridoxine_5''-phosphate <=> H2O2 + pyridoxal_5''-phosphate 1.4.3.5 pyridoxal 5'-phosphate synthase
–
L-galactopyranose + NAD+ <=> H+ + L-galactono-1,4-lactone + NADH 1.1.1.122 D-threo-aldose 1-dehydrogenase
1.1.1.316 L-galactose 1-dehydrogenase
–
–
riboflavin + ATP <=> FMN + ADP + H+ 2.7.1.161 CTP-dependent riboflavin kinase
2.7.1.26 riboflavin kinase
–
–
ATP + L-glutamine + HCO3- + H2O <=> L-glutamate + Carbamoyl_phosphate + ADP + phosphate + H+ 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
–
–
6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + O2 + reduced_acceptor <=> 3-demethyubiquinol + H2O + acceptor 1.14.99.60 3-demethoxyubiquinol 3-hydroxylase
–
Precorrin-6Y + NADP+ <=> precorrin-6A + NADPH + H+ 1.3.1.54 precorrin-6A reductase
–
2,3-Epoxymenaquinone + peptidyl-4-carboxyglutamate + H2O <=> menaquinol + peptidyl-glutamate + CO2 + O2 4.1.1.90 peptidyl-glutamate 4-carboxylase
–
4-hydroxyphenylpyruvate + O2 <=> CO2 + homogentisate 1.13.11.27 4-hydroxyphenylpyruvate dioxygenase
–
6-amino-6-deoxyfutalosine + H2O <=> dehypoxanthine_futalosine + adenine 3.2.2.16 methylthioadenosine nucleosidase
3.2.2.26 futalosine hydrolase
3.2.2.30 aminodeoxyfutalosine nucleosidase
–
–
–
thiamine_phosphate + ATP <=> thiamine_diphosphate + ADP 2.7.1.21 thymidine kinase
2.7.4.12 T2-induced deoxynucleotide kinase
2.7.4.13 (deoxy)nucleoside-phosphate kinase
2.7.4.16 thiamine-phosphate kinase
2.7.4.3 adenylate kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
2.7.4.9 dTMP kinase
–
–
–
–
–
–
–
–
L-tyrosine + S-adenosyl-L-methionine + reduced_acceptor <=> 2-iminoacetate + p-Cresol + 5''-deoxyadenosine + L-methionine + acceptor + 2 H+ 4.1.99.19 2-iminoacetate synthase
–
homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase
–
–
–
L-galactono-1,4-lactone + 2 ferricytochrome_c <=> ascorbate + 2 ferricytochrome_c + 2 H+ 1.3.2.3 L-galactonolactone dehydrogenase
–
S-adenosyl-L-methionine + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-tyrosine <=> 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + 5''-deoxyadenosine + L-methionine + H+ 2.5.1.147 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
–
chorismate <=> isochorismate 5.4.4.2 isochorismate synthase
–
Ni-sirohydrochlorin + H+ <=> sirohydrochlorin + Ni2+ 4.99.1.11 sirohydrochlorin nickelchelatase
–
pyridoxal_5''-phosphate + H2O <=> pyridoxal + phosphate 3.1.3.2 acid phosphatase
3.1.3.26 4-phytase
3.1.3.74 pyridoxal phosphatase
3.1.3.8 3-phytase
–
–
–
–
[glycine_cleavage_system_H]-N6-octanoyl-L-lysine + an_[Fe-S]_cluster_scaffold_protein_carrying_a_[4Fe-4S]2+_cluster + 2 S-adenosyl-L-methionine + 2 [2Fe-2S]-center + 8 H+ <=> dihydrolipoylprotein + an_[Fe-S]_cluster_scaffold_protein + 2 Sulfide + 4 Fe2+ + 2 L-methionine + 2 5''-Deoxyadenosine + 2 [2Fe-2S]-center 2.8.1.8 lipoyl synthase
–
L-galactono-1,4-lactone + H2O <=> L-galactonate + H+ 3.1.1
3.1.1.17 gluconolactonase
3.1.1.68 xylono-1,4-lactonase
–
–
–
stearoyl-[acyl-carrier_protein] + 2 reduced_flavodoxin + 3 O2 <=> pimeloyl-[acyl-carrier_protein] + an_n-alkanal + 2 flavin + 3 H2O 1.14.14.46 pimeloyl-[acyl-carrier protein] synthase
–
L-gulono-1,4-lactone + H2O <=> L-gulonate + H+ 3.1.1.17 gluconolactonase
3.1.1.25 1,4-lactonase
–
–
S-adenosyl-L-methionine + delta-tocopherol <=> S-adenosyl-L-homocysteine + beta-tocopherol + H+ 2.1.1.95 tocopherol C-methyltransferase
–
delta-tocopherol <=> 2-methyl-6-phytylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
cobalt-precorrin-6B + NAD+ <=> cobalt-precorrin-6A + NADH 1.3.1.106 cobalt-precorrin-6A reductase
–
L-dihydroorotate + H2O <=> H+ + L-carbamoyl-L-aspartate 3.5.2.3 dihydroorotase
–
Coproporphyrinogen-III + O2 + H+ <=> protoporphyrinogen-IX + CO2 + H2O 1.3.3.3 coproporphyrinogen oxidase
–
H+ + isochorismate + 2-oxoglutarate <=> (1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2 2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
–
GTP + coenzyme_F420-0 + L-glutamate <=> GDP + phosphate + coenzyme_F420-1 6.3.2.31 coenzyme F420-0:L-glutamate ligase
–
H+ + 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + H2O <=> 5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NH3 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase
–
dethiobiotin + Sulfur_donor + 2 S-adenosyl-L-methionine + 2 e- + 2 H+ <=> biotin + 2 L-methionine + 2 5''-Deoxyadenosine 2.8.1.6 biotin synthase
–
7,8-dihydroneopterin_3''-triphosphate + H2O <=> H+ + 7,8-dihydroneopterin_3''-phosphate + diphosphate 3.6.1.67 dihydroneopterin triphosphate diphosphatase
–
geranyl_diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate 2.5.1.39 4-hydroxybenzoate polyprenyltransferase
2.5.1.93 4-hydroxybenzoate geranyltransferase
–
–
FMNH2 + O2 <=> 5,6-Dimethylbenzimidazole + D-erythrose_4-phosphate + H2O 1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase
–
H+ + orotidine_5''-phosphate <=> CO2 + UMP 4.1.1.23 orotidine-5'-phosphate decarboxylase
–
L-aspartate + O2 <=> H+ + iminosuccinate + H2O2 1.4.3.16 L-aspartate oxidase
–
Glutaryl-[acp]_methyl_ester + malonyl-[acyl-carrier_protein] + H+ <=> 3-Ketopimeloyl-[acp]_methyl_ester + CO2 + [acyl-carrier_protein] 2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
–
–
7,8-dihydrofolate + NADP+ <=> folate + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
–
–
1-deoxy-D-xylulose_5-phosphate + 2-iminoacetate + Thiocarboxy-[sulfur-carrier_protein] <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl_phosphate + Sulfur-carrier_protein + 2 H2O 2.8.1.10 thiazole synthase
–
enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine + NADH + H+ 1.8.1.4 dihydrolipoyl dehydrogenase
–
L-gulonate + NADP+ <=> D-glucuronate + NADPH + H+ 1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.20 glucuronolactone reductase
1.1.1.21 aldose reductase
–
–
–
–
2-(2-carboxy-4-methylthiazol-5-yl)ethyl_phosphate + 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + H+ <=> thiamine_phosphate + CO2 + diphosphate 2.5.1.3 thiamine phosphate synthase
–
alpha-ribazole_5''-phosphate + H2O <=> alpha-ribazole + phosphate 3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
S-adenosyl-L-methionine + Coproporphyrinogen-III <=> protoporphyrinogen-IX + CO2 + L-methionine + 5''-deoxyadenosine 1.3.98.3 coproporphyrinogen dehydrogenase
–
octanoyl-CoA + Lipoyl-carrier_protein_E2 <=> [Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine + CoA 2.3.1
–
3''-dephospho-CoA + ATP <=> H+ + CoA + ADP 2.7.1.24 dephospho-CoA kinase
–
S-adenosyl-L-methionine + 2-methyl-6-phytylbenzene-1,4-diol <=> H+ + 2,3-dimethyl-6-phytylbenzene-1,4-diol + S-adenosyl-L-homocysteine 2.1.1.295 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
–
beta-carotene + O2 <=> all-trans-retinal 1.13.11.63 beta-carotene 15,15'-dioxygenase
–
Coproporphyrinogen-III + O2 <=> coproporphyrin_III + H2O2 1.3.3.15 coproporphyrinogen III oxidase (coproporphyrin-forming)
1.3.3.4 protoporphyrinogen oxidase
–
–
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O <=> 6-amino-6-deoxyfutalosine + L-methionine + HCO3- + H+ 2.5.1.120 aminodeoxyfutalosine synthase
–
(2S)-2-amino-3-oxo-4-phosphonooxybutanoate + H+ <=> 3-amino-1-hydroxyacetone_1-phosphate + CO2 0.0.0.0
1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase
–
–
12,18-didecarboxysiroheme <=> Fe-coproporphyrin_III not assigned
 –
2-polyprenylphenol + O2 + NADPH + H+ <=> 2-polyprenyl-6-hydroxyphenol + H2O + NADP+ 1.14.13.240 2-polyprenylphenol 6-hydroxylase
–
3-aminopropionaldehyde + NAD+ + H2O <=> H+ + beta-Alanine + NADH 1.2.1
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
–
–
–
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate <=> 7,8-dihydroneopterin_3''-phosphate + H2O 4.2.1.160 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
–
7,8-dihydrofolate + NADH + H+ <=> tetrahydrofolate + NAD+ 1.5.1.3 dihydrofolate reductase
–
GDP-beta-L-galactose + phosphate <=> H+ + GDP + beta-L-galactose_1-phosphate 2.7.7.69 GDP-L-galactose phosphorylase
–
S-adenosyl-L-methionine + cobalt-precorrin-7 <=> cobalt-precorrin-8 + S-adenosyl-L-homocysteine 2.1.1.289 cobalt-precorrin-7 (C5)-methyltransferase
–
S-adenosyl-L-methionine + 2-polyprenyl-6-hydroxyphenol <=> 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+ 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase
–
menaquinone + NADH + H+ <=> menaquinol + NAD+ 1.6.5
1.6.5.2 NAD(P)H dehydrogenase (quinone)
1.6.5.9 NADH:quinone reductase (non-electrogenic)
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
7.2.1.1 NADH:ubiquinone reductase (Na+-transporting)
–
–
–
–
–
glycine + protein + NAD+ <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + [Protein]-dehydroalanine + H2O + H+ 2.4.2.60 cysteine-dependent adenosine diphosphate thiazole synthase
–
cobalt-factor_III <=> cobalt-precorrin-3B not assigned
 –
S-adenosyl-L-methionine + gamma-tocopherol <=> S-adenosyl-L-homocysteine + alpha-tocopherol + H+ 2.1.1.95 tocopherol C-methyltransferase
–
ATP + deamido-NAD+ + L-glutamine + H2O <=> H+ + L-glutamate + AMP + diphosphate + NAD+ 6.3.1.5 NAD+ synthase
6.3.5.1 NAD+ synthase (glutamine-hydrolysing)
–
–
cobalt-precorrin-5A + H2O <=> H+ + cobalt-precorrin-5B + acetaldehyde 3.7.1.12 cobalt-precorrin 5A hydrolase
–
GTP + coenzyme_F420-1 + L-glutamate <=> GDP + phosphate + coenzyme_gamma-F420-2 6.3.2.34 coenzyme F420-1:gamma-L-glutamate ligase
–
adenosylcobinamide + GTP <=> adenosylcobinamide_phosphate + GDP + H+ 2.7.1.156 adenosylcobinamide kinase
–
6-amino-6-deoxyfutalosine + H2O + H+ <=> futalosine + NH3 3.5.4.40 aminodeoxyfutalosine deaminase
–
protoporphyrinogen-IX + 3 1,4-benzoquinone <=> protoporphyrin_IX + 3 hydroquinone 1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone)
–
S-adenosyl-L-methionine + precorrin-4 <=> precorrin-5 + S-adenosyl-L-homocysteine + H+ 2.1.1.133 precorrin-4 C11-methyltransferase
2.1.1.271 cobalt-precorrin-4 methyltransferase
–
–
folate + NADH <=> tetrahydrofolate + NAD+ 1.5.1.3 dihydrofolate reductase
1.5.1.34 6,7-dihydropteridine reductase
–
–
H+ + trihomocitrate + CoA <=> 2-oxopimelic_acid + acetyl-CoA + H2O 2.3.3
4.1.3
–
–
2,3-Epoxymenaquinone + dithiothreitol <=> menaquinone + oxidized_dithiothreitol + H2O 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)
–
nicotinic_acid_mononucleotide + ATP + H+ <=> deamido-NAD+ + diphosphate 2.7.7.1 nicotinamide-nucleotide adenylyltransferase
2.7.7.18 nicotinate-nucleotide adenylyltransferase
–
–
all-trans-retinol + NAD+ <=> all-trans-retinal + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.105 all-trans-retinol dehydrogenase (NAD+)
1.1.1.300 NADP-retinol dehydrogenase
1.1.1.315 11-cis-retinol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
–
–
–
–
–
5,6,7,8-tetrahydromethanopterin + L-glutamate + ATP <=> H+ + tetrahydrosarcinapterin + ADP + phosphate 6.3.2.33 tetrahydrosarcinapterin synthase
–
ATP + UTP + L-glutamine + H2O <=> H+ + ADP + phosphate + CTP + L-glutamate 6.3.4.2 CTP synthase (glutamine hydrolysing)
–
ATP + UMP <=> ADP + UDP 2.7.4.14 UMP/CMP kinase
2.7.4.22 UMP kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
–
–
–
–
H2O + GTP <=> H+ + diphosphate + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate 3.5.4.25 GTP cyclohydrolase II
–
D-ribulose_5-phosphate <=> H+ + formate + L-3,4-dihydroxybutan-2-one_4-phosphate 4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
–
ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole <=> H+ + ADP + 2-(4-methyl-1,3-thiazol-5-yl)ethyl_phosphate 2.7.1.50 hydroxyethylthiazole kinase
–
thiamine_phosphate + H2O <=> thiamine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.100 thiamine phosphate phosphatase
3.1.3.2 acid phosphatase
–
–
–
(S)-4-Amino-5-oxopentanoate + NADP+ + tRNAMet <=> Glu-tRNAGln + NADPH + H+ 1.2.1.70 glutamyl-tRNA reductase
–
Fe-coproporphyrin_III + H+ <=> coproporphyrin_III + Fe2+ 4.99.1.9 coproporphyrin ferrochelatase
–
7,8-dihydroneopterin_3''-phosphate + H2O <=> 7,8-dihydroneopterin + phosphate 3.6.1
–
NAD+ + glycine + Sulfide <=> nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + H2O + H+ 2.4.2.59 sulfide-dependent adenosine diphosphate thiazole synthase
–
nicotinate + 5-phospho-alpha-D-ribose_1-diphosphate + ATP + H2O <=> nicotinic_acid_mononucleotide + diphosphate + ADP + phosphate 6.3.4.21 nicotinate phosphoribosyltransferase
–
L-glutamate + 7,8-dihydropteroate + ATP <=> H+ + 7,8-dihydrofolate + phosphate + ADP 6.3.2.12 dihydrofolate synthase
6.3.2.17 tetrahydrofolate synthase
–
–
malonyl-[acyl-carrier_protein]_methyl_ester + malonyl-[acyl-carrier_protein] + H+ <=> 3-Ketoglutaryl-[acp]_methyl_ester + CO2 + [acyl-carrier_protein] 2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
–
–
H+ + alpha-D-mannose_1-phosphate + GTP <=> GDP-mannose + diphosphate 2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase
–
–
–
–
pyruvate + ATP <=> H+ + phosphoenolpyruvate + ADP 2.7.1.40 pyruvate kinase
–
H+ + (R)-4''-phosphopantothenoyl-L-cysteine <=> 4''-phosphopantetheine + CO2 4.1.1.36 phosphopantothenoylcysteine decarboxylase
–
H+ + L-aspartate <=> beta-Alanine + CO2 4.1.1.11 aspartate 1-decarboxylase
4.1.1.15 glutamate decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.29 sulfinoalanine decarboxylase
–
–
–
–
D-glyceraldehyde_3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde_phosphate + H2O + phosphate 4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase
–
adenosylcobinamide + ATP <=> H+ + adenosylcobinamide_phosphate + ADP 2.7.1.156 adenosylcobinamide kinase
–
FMN + ATP + H+ <=> FAD + diphosphate 2.7.7.2 FAD synthase
–
ATP + (R)-pantoate <=> H+ + ADP + (R)-4-phosphopantoate 2.7.1.169 pantoate kinase
–
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl_phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl_phosphate 5.3.99.10 thiazole tautomerase
–
uroporphyrinogen_III + H+ <=> Coproporphyrinogen-III + CO2 4.1.1.37 uroporphyrinogen decarboxylase
–
S-adenosyl-L-methionine + cobalt-precorrin-3B <=> cobalt-precorrin-4 + S-adenosyl-L-homocysteine 2.1.1.131 precorrin-3B C17-methyltransferase
–
L-kynurenine + O2 + NADPH + H+ <=> L-3-hydroxykynurenine + H2O + NADP+ 1.14.13.9 kynurenine 3-monooxygenase
–
trihomocitrate <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase
–
S-adenosyl-L-methionine + demethylphylloquinol <=> vitamin_KH2 + S-adenosyl-L-homocysteine + H+ 2.1.1.329 demethylphylloquinol methyltransferase
–
L-cysteine + [enzyme]-cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine 2.8.1.7 cysteine desulfurase
–
S-adenosyl-L-methionine + cobalt-precorrin-6B + H+ <=> cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2 2.1.1.196 cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
–
spermine + O2 + H2O <=> spermidine + 3-aminopropionaldehyde + H2O2 1.5.3.16 spermine oxidase
1.5.3.17 non-specific polyamine oxidase
–
–
GTP + H2O <=> H+ + formate + 7,8-dihydroneopterin_3''-triphosphate 3.5.4.16 GTP cyclohydrolase I
–
L-tryptophan + O2 <=> N-formyl-L-kynurenine 1.13.11.11 tryptophan 2,3-dioxygenase
1.13.11.26 peptide-tryptophan 2,3-dioxygenase
1.13.11.52 indoleamine 2,3-dioxygenase
–
–
–
7,8-dihydrofolate + NAD+ <=> folate + NADH + H+ 1.5.1.3 dihydrofolate reductase
–
ATP + cob(I)alamin <=> tripolyphosphate + adenosylcobalamin 2.5.1.17 corrinoid adenosyltransferase
–
protoporphyrinogen-IX + O2 <=> protoporphyrin_IX + H2O2 1.3.3.4 protoporphyrinogen oxidase
–
pyridoxal_5'-phosphate + L-histidine <=> 2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate not assigned
 –
cyclic_pyranopterin_phosphate + 2 Thiocarboxy-[sulfur-carrier_protein] <=> molybdopterin + 2 Sulfur-carrier_protein 2.8.1.12 molybdopterin synthase
–
heme + H+ <=> protoporphyrin_IX + Fe2+ 4.99.1.1 protoporphyrin ferrochelatase
4.99.1.9 coproporphyrin ferrochelatase
–
–
UDP-glucose + H2O + NAD+ <=> UDP-glucuronate + NADH + H+ 1.1.1.22 UDP-glucose 6-dehydrogenase
–
ATP + UTP + NH3 <=> ADP + phosphate + CTP + H+ 6.3.4.2 CTP synthase (glutamine hydrolysing)
–
1,4-dihydroxy-2-naphthoate <=> 2-carboxy-1,4-naphthoquinone not assigned
 –
FMNH2 + NADP+ <=> FMN + NADPH + H+ 1.18.1.2 ferredoxin---NADP+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
1.5.1.45 FAD reductase [NAD(P)H]
–
–
–
–
–
–
–
–
–
S-adenosyl-L-methionine + cobalt-precorrin-5B <=> cobalt-precorrin-6A + S-adenosyl-L-homocysteine 2.1.1.195 cobalt-precorrin-5B (C1)-methyltransferase
–
precorrin-2 + NAD+ <=> H+ + sirohydrochlorin + NADH 1.3.1.76 precorrin-2 dehydrogenase
–
heme + (2E,6E)-farnesyl_diphosphate + H2O <=> heme_O + diphosphate 2.5.1.141 heme o synthase
–
porphobilinogen + H2O <=> Hydroxymethylbilane + NH3 2.5.1.61 hydroxymethylbilane synthase
–
H2O + thiamine <=> H+ + 4-methyl-5-(2-hydroxyethyl)-thiazole + 4-Amino-5-hydroxymethyl-2-methylpyrimidine 3.5.99.2 aminopyrimidine aminohydrolase
–
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate <=> 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-homocysteine + H+ 2.1.1.114 polyprenyldihydroxybenzoate methyltransferase
–
D-ribose_5-phosphate + D-glyceraldehyde_3-phosphate + L-glutamine <=> pyridoxal_5''-phosphate + L-glutamate + 3 H2O + phosphate 4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
–
2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + NAD+ <=> 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + NADH + H+ 1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
–
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)
–
–
(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> homoisocitrate 4.2.1.114 methanogen homoaconitase
–
(-)-threo-iso(homo)2citrate + NAD+ <=> 2-oxopimelic_acid + CO2 + NADH 1.1.1
–
7,8-dihydroneopterin_3''-triphosphate <=> 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde_triphosphate 4.1.2.60 dihydroneopterin triphosphate aldolase
–
3-geranyl-4-hydroxybenzoate + O2 <=> 3,4-dihydroxy-5-all-trans-polyprenylbenzoate not assigned
 –
[enzyme]-S-sulfanylcysteine + Adenylyl-[sulfur-carrier_protein] + reduced_acceptor <=> AMP + Thiocarboxy-[sulfur-carrier_protein] + [enzyme]-cysteine + acceptor 2.8.1.11 molybdopterin synthase sulfurtransferase
2.8.1.4 tRNA uracil 4-sulfurtransferase
–
–
tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
1.5.1.50 dihydromonapterin reductase
–
–
–
–
chorismate <=> 4-hydroxybenzoate + pyruvate 4.1.3.40 chorismate lyase
–
2-carboxy-1,4-naphthoquinone + phytyl_diphosphate + H+ <=> demethylphylloquinone + diphosphate + CO2 2.5.1.130 2-carboxy-1,4-naphthoquinone phytyltransferase
–
L-lysine + (8S)-8-amino-7-oxononanoate <=> (S)-2-amino-6-oxohexanoate + (7R,8S)-diaminononanoate 2.6.1.105 lysine---8-amino-7-oxononanoate transaminase
–
4-(beta-D-ribofuranosyl)aminobenzene-5''-phosphate + 6-hydroxymethyl-7,8-dihydropterin_diphosphate <=> 7,8-dihydropterin-6-ylmethyl-4-(beta-D-ribofuranosyl)aminobenzene_5''-phosphate + diphosphate 2.5.1.105 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase
–
L-aspartate + IMP + GTP <=> H+ + adenylosuccinate + phosphate + GDP 6.3.4.4 adenylosuccinate synthase
–
NADH + vitamin_K + H+ <=> NAD+ + vitamin_KH2 1.6.5.2 NAD(P)H dehydrogenase (quinone)
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
–
–
S-adenosyl-L-methionine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil <=> coenzyme_F0 + 5''-deoxyadenosine + L-methionine + NH3 + H+ 4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
–
H+ + 4-(2''-carboxyphenyl)-4-oxobutyryl-CoA <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O 4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase
–
H+ + molybdopterin + ATP <=> adenylyl-molybdopterin + diphosphate 2.7.7.75 molybdopterin adenylyltransferase
–
S-adenosyl-L-methionine + cobalt-sirohydrochlorin <=> H+ + S-adenosyl-L-homocysteine + cobalt-factor_III 2.1.1.151 cobalt-factor II C20-methyltransferase
–
GDP-mannose <=> GDP-beta-L-galactose 5.1.3.18 GDP-mannose 3,5-epimerase
–
biopterin + NADPH + H+ <=> dihydrobiopterin + NADP+ 1.5.1.33 pteridine reductase
–
tetrahydrofolate + L-glutamate + ATP <=> tetrahydrofolate + ADP + phosphate 6.3.2.17 tetrahydrofolate synthase
–
ATP + pyridoxine <=> H+ + ADP + pyridoxine_5''-phosphate 2.7.1.35 pyridoxal kinase
2.7.1.49 hydroxymethylpyrimidine kinase
–
–
cobyrinate + L-glutamine + ATP + H2O <=> cob(II)yrinic_acid_a,c-diamide + L-glutamate + ADP + phosphate + H+ 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
CDP + ATP <=> CTP + ADP 2.7.4.3 adenylate kinase
2.7.4.6 nucleoside-diphosphate kinase
–
–
o-succinylbenzoate + CoA + ATP <=> 4-(2''-carboxyphenyl)-4-oxobutyryl-CoA + AMP + diphosphate 6.2.1.26 o-succinylbenzoate---CoA ligase
–
S-adenosyl-L-methionine + cobalt-precorrin-4 <=> S-adenosyl-L-homocysteine + cobalt-precorrin-5A + H+ 2.1.1.271 cobalt-precorrin-4 methyltransferase
–
2-sulfoacetaldehyde <=> coenzyme_M not assigned
 –
L-threo-tetrahydrobiopterin + 2 NADP+ <=> 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
1.1.1.325 sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
–
–
H+ + 1-phospho-alpha-D-galacturonate + UTP <=> UDP-D-galacturonate + diphosphate 2.7.7
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
–
–
ATP + adenosylcobyric_acid + (R)-1-aminopropan-2-yl_phosphate <=> ADP + adenosylcobinamide_phosphate + phosphate + H+ 6.3.1.10 adenosylcobinamide-phosphate synthase
–
3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate <=> 2-polyprenyl-6-methoxyphenol + CO2 4.1.1
–
L-dihydroorotate + NAD+ <=> H+ + Orotate + NADH 1.3.1.14 dihydroorotate dehydrogenase (NAD+)
–
2-(4-methyl-1,3-thiazol-5-yl)ethyl_phosphate + 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + H+ <=> thiamine_phosphate + diphosphate 2.5.1.3 thiamine phosphate synthase
–
tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate 6.3.4.3 formate---tetrahydrofolate ligase
–
6-hydroxymethyl-7,8-dihydropterin_diphosphate + 4-Aminobenzoic_acid <=> 7,8-dihydropteroate + diphosphate 2.5.1.15 dihydropteroate synthase
–
gamma-glutamyltyramine + [5-(aminomethyl)furan-3-yl]methyl_diphosphate <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate 2.5.1.131 (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
–
L-aspartate + NAD+ <=> iminosuccinate + NADH + H+ 1.4.1.21 aspartate dehydrogenase
–
5-aminolevulinate <=> H+ + H2O + porphobilinogen 4.2.1.24 porphobilinogen synthase
–
FMNH2 + NAD+ <=> FMN + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
–
–
–
–
–
–
–
–
–
–
D-galacturonate + NADPH + H+ <=> L-galactonate + NADP+ 1.1.1
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.203 uronate dehydrogenase
1.1.1.21 aldose reductase
1.1.1.365 D-galacturonate reductase
–
–
–
–
–
siroheme + H+ <=> 12,18-didecarboxysiroheme + CO2 4.1.1.111 siroheme decarboxylase
–
Sulfur-carrier_protein + ATP <=> Adenylyl-[sulfur-carrier_protein] + diphosphate 2.7.7.73 sulfur carrier protein ThiS adenylyltransferase
2.7.7.80 molybdopterin-synthase adenylyltransferase
–
–
L-glutamate + tyramine + ATP <=> gamma-glutamyltyramine + ADP + phosphate + H+ 6.3.4.24 tyramine---L-glutamate ligase
–
(R)-4''-phosphopantothenate + L-cysteine + ATP <=> H+ + (R)-4''-phosphopantothenoyl-L-cysteine + diphosphate + AMP 6.3.2.51 phosphopantothenate---cysteine ligase (ATP)
–
3-Hydroxypimeloyl-[acp]_methyl_ester + NADP+ <=> 3-Ketopimeloyl-[acp]_methyl_ester + NADPH + H+ 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
–
4-amino-4-deoxychorismate <=> H+ + 4-Aminobenzoic_acid + pyruvate 4.1.3.38 aminodeoxychorismate lyase
–
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase
–
4-phosphooxy-L-threonine + 2-oxoglutarate <=> 3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + L-glutamate 2.6.1.52 phosphoserine transaminase
–
nicotinic_acid_mononucleotide + diphosphate + CO2 <=> 5-phospho-alpha-D-ribose_1-diphosphate + quinolinic_acid + H+ 2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)
–
adenosylcobinamide-GDP + alpha-ribazole <=> H+ + adenosylcobalamin + GMP 2.7.8.26 adenosylcobinamide-GDP ribazoletransferase
–
phytyl_diphosphate + homogentisate + H+ <=> 2-methyl-6-phytylbenzene-1,4-diol + CO2 + diphosphate 2.5.1.115 homogentisate phytyltransferase
–
H+ + pimeloyl-CoA + L-alanine <=> CO2 + CoA + (8S)-8-amino-7-oxononanoate 2.3.1.47 8-amino-7-oxononanoate synthase
–
D-erythrose_4-phosphate + NAD+ + H2O <=> 4-phospho-D-erythronate + NADH + H+ 1.2.1.72 erythrose-4-phosphate dehydrogenase
–
(2R)-O-phospho-3-sulfolactate <=> phosphoenolpyruvate + sulfite + H+ 4.4.1.19 phosphosulfolactate synthase
–
FADH2 + NAD+ <=> FAD + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.2 ferredoxin---NADP+ reductase
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.3.1.116 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
1.5.1.45 FAD reductase [NAD(P)H]
1.6.99.3 NADH dehydrogenase
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
–
–
–
–
–
–
–
–
–
–
–
–
gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydrofolate + NADH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)
–
–
Enoylglutaryl-[acp]_methyl_ester + NADPH + H+ <=> Glutaryl-[acp]_methyl_ester + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
–
glycine + O2 <=> 2-iminoacetate + H2O2 + H+ 1.4.3.19 glycine oxidase
–
S-adenosyl-L-methionine + Precorrin-6Y <=> precorrin-8X + S-adenosyl-L-homocysteine + CO2 + H+ 2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating)
–
7,8-Dihydroneopterin_3''-triphosphate + 3 H2O <=> 7,8-dihydroneopterin + 3 phosphate 3.1.3.1 alkaline phosphatase
–
pimeloyl-[acyl-carrier_protein] + L-alanine + H+ <=> (8S)-8-amino-7-oxononanoate + CO2 + [acyl-carrier_protein] 2.3.1.47 8-amino-7-oxononanoate synthase
–
(7R,8S)-diaminononanoate + CO2 + ATP <=> dethiobiotin + phosphate + ADP + H+ 6.3.3.3 dethiobiotin synthase
–
(2R)-3-sulfolactate + NAD+ <=> H+ + 3-sulfopyruvate + NADH 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
–
–
–
2-oxoglutarate + H2O + acetyl-CoA <=> H+ + (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA 2.3.3.14 homocitrate synthase
–
adenylosuccinate <=> fumarate + AMP 4.3.2.2 adenylosuccinate lyase
–

Visualization of the pathway